A positive result will see the gap closed to the play-offs to four points, with sixth-placed Bolton not in action.
John Mousinho has to contend with selection issues, however, with Joe Pigott suspended and both Joe Morrell and Dane Scarlett away on international duty.
This is how we think the Blues head coach will go against the League One new boys.
1. Pompey predicted line-up
Pompey have players away on international duty against Port Vale. Photo: Jason Brown
2. GK Matt Macey
The rise continues after another excellent showing at Bristol Rovers. Photo: Jason Brown
3. RB Joe Rafferty
So reassuring to have the Scouser back, especially with Zak Swanson out of contention at the moment. Photo: Jason Brown
4. CB Sean Raggett
Been rock solid with the central defender in the kind of form which saw him earn player of the season success last term. Photo: Jason Brown